ExDom is a unique database developed for the integrated comparative visualization and analysis of the domain structure of different proteins in different proteomes that contain a common domain correlated to the exon-intron structure of the split genes which code for these proteins. Currently, all the proteins from seven different proteomes, and the corresponding genes from the seven genomes can be compared simultaneously.

The various protein domains of the protein are visualized against the exons of the gene that code for the domains in a linear mode.

ExDom enables further analysis to be carried out on the three dimensional structure of the protein, by color coding the various protein structural regions that corresponds to the different exonic regions of the gene.

ExDom database is integrated with 3743 protein domains annotated in the Pfam database to their corresponding exon-intron structures in 37,178 genes annotated in the RefSeq database.

Features:

• ExDom is a unique repository which provides Exon-Domain correlation for seven eukaryotes
• ExDom is implemented using high-end technologies such as Flash MX 6
• ExDom allows users to query for a domain of interest, retrieve all proteins across different genomes that contain that domain. One can then compare the exon-intron structure of the different genes, and simultaneously compare the domain structures of the different proteins correlated to the exon-intron structure.
• The Salient features of ExDom are
  

  Graphical Visualization of exon-domain relationships Multiple Sequence Alignment of domain in protein hits Visualization of the tertiary structures of proteins color coded to display the exon-regions of genes on the proteins Gene and protein details with links to various databases Tertiary structure Comparative Viewer that enables the comparative view of the ExDom 3D plots of multiple proteins

• ExDom distinguishes itself from databases such as ProSAS and GeneSpeed with its unique capabilities for in-depth comparative analysis of the exon-intron distribution of different proteins sharing common domains
• xDom could serve as a powerful tool for exploring several key questions concerning protein and gene evolution