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EuSplice is a powerful one-stop information resource for investigating almost any questions concerning the molecular mechanisms of complex splicing events, disease associations and the evolution of splicing in 23 different eukaryotic organisms. EuSplice in one of the most appreciated and recognized database by the research community such as NCBI, by providing external links of EuSplice in their site.
Features:
- EuSplice provides reliable splice signal and Alternative Splicing (AS) information for 23 eukaryotes, whose complete genome data is available. It is adding new genomes to the list as new genome data become available.
- EuSplice database contains 2.1 million splice signals and 95822 AS events associated with over 270 , 000 protein-coding genes .
- EuSplice web interface is embedded with intuitive and user-friendly query system and has powerful data mining and graphics capabilities.
- EuSplice provides inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events.
- EuSplice has integration of splicing data to extensive gene-specific annotations, such as homolog annotations, functional information, mutations and sequence details.
- EuSplice is also equipped with advanced tools such as
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- Splice blast
- Splice match
- Genome Position weight matrix
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Applications:
- One can explore the genome of any of the 23 organisms in the EuSplice database with almost any type of analysis that concerns RNA splicing. As mutations within the splice signal sequences are supposed to cause nearly 50% of all human diseases, EuSplice offers the power to analyze mutational events, exon-splicing changes in genes, diseases associated with such mutations and exon-splicing changes, and a plethora of additional information. EuSplice utilizes the available genome annotation data for a comprehensive in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in these eukaryote genomes.
- EuSplice Alternative Splice plots facilitates understanding the diversity produced by AT and AS events important role in tissue-specific gene expression, protein diversity, gene expression regulation, and disease manifestation.
- The EuSplice resource is available at http://66.170.16.154/EuSplice
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