Background:
Alternative splicing is a possible way of generating diversity of proteins from a set of genes. By splicing different sets of exons of a gene, a number of coding sequences can be generated, and, thereby a number of protein sequences. Biologists think that this process generates a large number of proteins from the genome of an organism.
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Description:
AspAlt—a web-based tool for comparative analysis of alternative splicing (AS) and alternative transcription (AT) events. |
Features: |
- AspAlt is one of the largest and the first resource which allows in-depth comparative analysis of AT/AS patterns of multiple genes in a single user-friendly graphical platform with color coded AT/AS graphical display options.
- AspAlt utilizes a unique AT/AS classification algorithm to identify specific AT/AS events from Intron-exon position data of mRNA annotations of genomes.
- AspAlt is embedded with friendly analytical features such as
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- Advanced graphical display to visualize and analyze AT/AS events in eukaryotic genomes.
- Compare and identify the differences in AT/AS patterns in a group of genes specified by the user or in homologous gene groups using a consolidated graphical viewer.
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| Applications: |
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- Analyzing gene expression data generated from splice arrays identifying tissue-specific variations in AS events
- Comparing AT/AS profiles in normal and disease gene expression data
- Analyzing evolutionary analysis of the variations in AT/AS event variations
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- AspAlt facilitate on understanding the diversity produced by AT and AS events important role in tissue-specific gene expression, protein diversity, gene expression regulation, and disease manifestation.
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